APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

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Abstract

Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.

The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with APOE alleles are not directly captured in a regular genome-wide association study (GWAS), where each SNP is investigated separately. We derived the 3 common APOE alleles and investigated the interplay between APOE, age at ischemic stroke onset, severity, sex, and outcome within a large international collaboration, the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network.

Detaljer

Författare
  • Cecilia Lagging
  • Erik Lorentzen
  • Tara M. Stanne
  • Annie Pedersen
  • Martin Söderholm
  • John W. Cole
  • Katarina Jood
  • Robin Lemmens
  • Chia Ling Phuah
  • Natalia S. Rost
  • Vincent Thijs
  • Daniel Woo
  • Jane M. Maguire
  • Arne Lindgren
  • Christina Jern
  • Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network
  • International Stroke Genetics Consortium
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Göteborgs universitet
  • Baltimore VA Medical Center
  • University of Maryland
  • Catholic University of Leuven
  • University Hospitals Leuven
  • Washington University in St. Louis
  • Massachusetts General Hospital
  • Harvard University
  • University of Melbourne
  • Austin Health
  • University of Cincinnati
  • University of Technology Sydney
  • Hunter Medical Research Institute, Australia
  • Sahlgrenska University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
Originalspråkengelska
Sidor (från-till)849-853
Antal sidor5
TidskriftNeurology
Volym93
Utgåva nummer19
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa