Apoptins: selective anticancer agents

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Standard

Apoptins: selective anticancer agents. / Rollano Penaloza, Oscar Miguel; Lewandowska, Magdalena ; Stetefeld, Joerg; Ossysek, Karolina ; Madej, Mariusz ; Bereta, Joanna; Sobczak, Mateusz; Shojaei, Shahla; Ghavami, Saeid; Los, Marek.

I: Trends in Molecular Medicine, Vol. 20, Nr. 9, 19.08.2014, s. 519-528.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

Rollano Penaloza, OM, Lewandowska, M, Stetefeld, J, Ossysek, K, Madej, M, Bereta, J, Sobczak, M, Shojaei, S, Ghavami, S & Los, M 2014, 'Apoptins: selective anticancer agents', Trends in Molecular Medicine, vol. 20, nr. 9, s. 519-528. https://doi.org/10.1016/j.molmed.2014.07.003

APA

Rollano Penaloza, O. M., Lewandowska, M., Stetefeld, J., Ossysek, K., Madej, M., Bereta, J., ... Los, M. (2014). Apoptins: selective anticancer agents. Trends in Molecular Medicine, 20(9), 519-528. https://doi.org/10.1016/j.molmed.2014.07.003

CBE

Rollano Penaloza OM, Lewandowska M, Stetefeld J, Ossysek K, Madej M, Bereta J, Sobczak M, Shojaei S, Ghavami S, Los M. 2014. Apoptins: selective anticancer agents. Trends in Molecular Medicine. 20(9):519-528. https://doi.org/10.1016/j.molmed.2014.07.003

MLA

Vancouver

Rollano Penaloza OM, Lewandowska M, Stetefeld J, Ossysek K, Madej M, Bereta J et al. Apoptins: selective anticancer agents. Trends in Molecular Medicine. 2014 aug 19;20(9):519-528. https://doi.org/10.1016/j.molmed.2014.07.003

Author

Rollano Penaloza, Oscar Miguel ; Lewandowska, Magdalena ; Stetefeld, Joerg ; Ossysek, Karolina ; Madej, Mariusz ; Bereta, Joanna ; Sobczak, Mateusz ; Shojaei, Shahla ; Ghavami, Saeid ; Los, Marek. / Apoptins: selective anticancer agents. I: Trends in Molecular Medicine. 2014 ; Vol. 20, Nr. 9. s. 519-528.

RIS

TY - JOUR

T1 - Apoptins: selective anticancer agents

AU - Rollano Penaloza, Oscar Miguel

AU - Lewandowska, Magdalena

AU - Stetefeld, Joerg

AU - Ossysek, Karolina

AU - Madej, Mariusz

AU - Bereta, Joanna

AU - Sobczak, Mateusz

AU - Shojaei, Shahla

AU - Ghavami, Saeid

AU - Los, Marek

PY - 2014/8/19

Y1 - 2014/8/19

N2 - •Apoptins are viral proteins that trigger cell death.•Apoptins show cancer-selective toxicity.•Potential delivery methods are being assayed for future apoptin clinical trials.Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies.

AB - •Apoptins are viral proteins that trigger cell death.•Apoptins show cancer-selective toxicity.•Potential delivery methods are being assayed for future apoptin clinical trials.Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies.

KW - anticancer agents

KW - anaphase-promoting complex

KW - CDK2

KW - protein kinase C

KW - protein phosphatase 2A

U2 - 10.1016/j.molmed.2014.07.003

DO - 10.1016/j.molmed.2014.07.003

M3 - Review article

VL - 20

SP - 519

EP - 528

JO - Trends in Molecular Medicine

T2 - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 9

ER -