Applying the ATN scheme in a memory clinic population: The ABIDE project

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

OBJECTIVE: To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS: We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia: 66 ± 10 years, 58% M) classified for positivity (±) of amyloid (A) ([18F]Florbetaben PET), tau (T) (CSF p-tau), and neurodegeneration (N) (medial temporal lobe atrophy). We assessed ATN profiles' demographic, clinical, and cognitive features at baseline, and cognitive decline over time. RESULTS: The proportion of A+T+N+ patients increased with syndrome severity (from 1% in SCD to 14% in MCI and 35% in dementia), while the opposite was true for A-T-N- (from 48% to 19% and 6%). Compared to A-T-N-, patients with the Alzheimer disease profiles (A+T+N- and A+T+N+) were older (both p < 0.05) and had a higher prevalence of APOE ε4 (both p < 0.05) and lower Mini-Mental State Examination (MMSE) (both p < 0.05), memory (both p < 0.05), and visuospatial abilities (both p < 0.05) at baseline. Non-Alzheimer profiles A-T-N+ and A-T+N+ showed more severe white matter hyperintensities (both p < 0.05) and worse language performance (both p < 0.05) than A-T-N-. A linear mixed model showed faster decline on MMSE over time in A+T+N- and A+T+N+ (p = 0.059 and p < 0.001 vs A-T-N-), attributable mainly to patients without dementia. CONCLUSIONS: The ATN scheme identified different biomarker profiles with overlapping baseline features and patterns of cognitive decline. The large number of profiles, which may have different implications in patients with vs without dementia, poses a challenge to the application of the ATN scheme.

Detaljer

Författare
  • Daniele Altomare
  • Arno de Wilde
  • Rik Ossenkoppele
  • Wiesje Pelkmans
  • Femke Bouwman
  • Colin Groot
  • Ingrid van Maurik
  • Marissa Zwan
  • Maqsood Yaqub
  • Frederik Barkhof
  • Bart N. van Berckel
  • Charlotte E. Teunissen
  • Giovanni B. Frisoni
  • Philip Scheltens
  • Wiesje M. van der Flier
Enheter & grupper
Externa organisationer
  • Vrije Universiteit Amsterdam
  • VU University Medical Center
  • Geneva University Hospital
  • University of Brescia
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi
Originalspråkengelska
Sidor (från-till)e1635-e1646
TidskriftNeurology
Volym93
Utgåva nummer17
StatusPublished - 2019 okt 22
PublikationskategoriForskning
Peer review utfördJa