Arterial blood pressure and long-term exposure to traffic-related air pollution: An analysis in the european study of cohorts for air pollution effects (ESCAPE)

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Abstract

Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. Methods: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. Results: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated. Conclusions: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.

Detaljer

Författare
  • Kateryna B. Fuks
  • Gudrun Weinmayr
  • Maria Foraster
  • Julia Dratva
  • Regina Hampel
  • Danny Houthuijs
  • Bente Oftedal
  • Sviatlana Panasevich
  • Johanna Penell
  • Johan N. Sommar
  • Mette Sørensen
  • Pekka Tiittanen
  • Kathrin Wolf
  • Wei W. Xun
  • Inmaculada Aguilera
  • Xavier Basagaña
  • Rob Beelen
  • Michiel L. Bots
  • Bert Brunekreef
  • H. Bas Bueno-de-Mesquita
  • Barbara Caracciolo
  • Marta Cirach
  • Ulf de Faire
  • Audrey de Nazelle
  • Marloes Eeftens
  • Roberto Elosua
  • Raimund Erbel
  • Bertil Forsberg
  • Laura Fratiglioni
  • Jean Michel Gaspoz
  • Agneta Hilding
  • Antti Jula
  • Michal Korek
  • Ursula Krämer
  • Nino Künzli
  • Timo Lanki
  • Karin Leander
  • Patrik K E Magnusson
  • Jaume Marrugat
  • Mark J. Nieuwenhuijsen
  • Claes Göran Östenson
  • Nancy L. Pedersen
  • Göran Pershagen
  • Harish C. Phuleria
  • Nicole M. Probst-Hensch
  • Ole Raaschou-Nielsen
  • Emmanuel Schaffner
  • Tamara Schikowski
  • Christian Schindler
  • Per E. Schwarze
  • Anne J. Søgaard
  • Dorothea Sugiri
  • Wim J R Swart
  • Ming Yi Tsai
  • Anu W. Turunen
  • Paolo Vineis
  • Annette Peters
  • Barbara Hoffmann
Enheter & grupper
Externa organisationer
  • Umeå University
Originalspråkengelska
Sidor (från-till)896-905
Antal sidor10
TidskriftEnvironmental Health Perspectives
Volym122
Utgivningsnummer9
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa