Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study

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Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study. / Simán, Henrik; Forsgren, Arne; Berglund, Göran; Florén, Claes-Henrik.

I: Scandinavian Journal of Gastroenterology, Vol. 32, Nr. 12, 1997, s. 1215-1221.

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Simán, Henrik ; Forsgren, Arne ; Berglund, Göran ; Florén, Claes-Henrik. / Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study. I: Scandinavian Journal of Gastroenterology. 1997 ; Vol. 32, Nr. 12. s. 1215-1221.

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TY - JOUR

T1 - Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study

AU - Simán, Henrik

AU - Forsgren, Arne

AU - Berglund, Göran

AU - Florén, Claes-Henrik

PY - 1997

Y1 - 1997

N2 - BACKGROUND: We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. METHODS: From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. RESULTS: The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year before diagnosis of gastric cancer could be a confounding factor. With exclusion of 10 such cases, H. pylori seropositivity among cases was 78%, as compared with 50% in matched controls (OR, 3.9; 95% CI, 1.7-9.2). Tumours of the cardia were not associated with H. pylori (OR, 0.92; 95% CI, 0.23-3.7), which is in contrast to tumours of the fundus, corpus, and antrum, which were significantly associated (OR, 11.1; 95% CI, 2.4-71.8). This difference in location was significant (P < 0.01). CONCLUSION: There is a significant association between prior infection with H. pylori and later development of gastric carcinoma, and the association is related to noncardia gastric cancer.

AB - BACKGROUND: We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. METHODS: From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. RESULTS: The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year before diagnosis of gastric cancer could be a confounding factor. With exclusion of 10 such cases, H. pylori seropositivity among cases was 78%, as compared with 50% in matched controls (OR, 3.9; 95% CI, 1.7-9.2). Tumours of the cardia were not associated with H. pylori (OR, 0.92; 95% CI, 0.23-3.7), which is in contrast to tumours of the fundus, corpus, and antrum, which were significantly associated (OR, 11.1; 95% CI, 2.4-71.8). This difference in location was significant (P < 0.01). CONCLUSION: There is a significant association between prior infection with H. pylori and later development of gastric carcinoma, and the association is related to noncardia gastric cancer.

KW - Gastric cancer

KW - Helicobacter pylori

KW - nested case—control study

U2 - 10.3109/00365529709028150

DO - 10.3109/00365529709028150

M3 - Article

VL - 32

SP - 1215

EP - 1221

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 1502-7708

IS - 12

ER -