Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception

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Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception. / Toft, Gunnar; Jönsson, Bo A; Lindh, Christian; Jensen, Tina Kold; Hjollund, Niels H.; Vested, Anne; Bonde, Jens Peter.

I: Environmental Health Perspectives, Vol. 120, Nr. 3, 2012, s. 458-463.

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Toft, G., Jönsson, B. A., Lindh, C., Jensen, T. K., Hjollund, N. H., Vested, A., & Bonde, J. P. (2012). Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception. Environmental Health Perspectives, 120(3), 458-463. https://doi.org/10.1289/ehp.1103552

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Toft, Gunnar ; Jönsson, Bo A ; Lindh, Christian ; Jensen, Tina Kold ; Hjollund, Niels H. ; Vested, Anne ; Bonde, Jens Peter. / Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception. I: Environmental Health Perspectives. 2012 ; Vol. 120, Nr. 3. s. 458-463.

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TY - JOUR

T1 - Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception

AU - Toft, Gunnar

AU - Jönsson, Bo A

AU - Lindh, Christian

AU - Jensen, Tina Kold

AU - Hjollund, Niels H.

AU - Vested, Anne

AU - Bonde, Jens Peter

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Animal studies indicate that some phthalate metabolites may harm female reproductive function. OBJECTIVES: We assessed the associations between exposure to phthalate metabolites and pregnancy loss. METHODS: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, is = 111). Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother. RESULTS: Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio (OR) = 2.9; 95% confidence interval (CI): 1.1, 7.6]. The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% Cl: 4.5, 369.5). CONCLUSIONS: The phthalate metabolite MEHP was associated with higher occurrence of pregnancy loss. Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.

AB - BACKGROUND: Animal studies indicate that some phthalate metabolites may harm female reproductive function. OBJECTIVES: We assessed the associations between exposure to phthalate metabolites and pregnancy loss. METHODS: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, is = 111). Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother. RESULTS: Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio (OR) = 2.9; 95% confidence interval (CI): 1.1, 7.6]. The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% Cl: 4.5, 369.5). CONCLUSIONS: The phthalate metabolite MEHP was associated with higher occurrence of pregnancy loss. Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.

KW - pregnancy loss

KW - phthalates

KW - MEHP

KW - abortion

U2 - 10.1289/ehp.1103552

DO - 10.1289/ehp.1103552

M3 - Article

VL - 120

SP - 458

EP - 463

JO - EHP Toxicogenomics

T2 - EHP Toxicogenomics

JF - EHP Toxicogenomics

SN - 1552-9924

IS - 3

ER -