Association between vitamin D, antimicrobial peptides and urinary tract infection in infants and young children

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Aim: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and β-defensin-2, which are expressed in the urinary tract. We investigated vitamin D status and levels of cathelicidin and β-defensin-2 and their association with urinary tract infection (UTI). Methods: The study included 120 children under three years of age: 76 children with UTIs and 44 otherwise healthy children with congenital hydronephrosis. Serum 25-hydroxycholecalciferol levels were measured by direct competitive electro-chemiluminescence immunoassay, and plasma cathelicidin and β-defensin-2 concentrations were analysed by enzyme-linked immunosorbent assay. Results: We found that vitamin D insufficiency and deficiency are prevalent in young children (21%). Serum vitamin D levels negatively correlated with age and were significantly lower in girls. Levels of vitamin D positively correlated with levels of cathelicidin but not with β-defensin-2. Low concentrations of vitamin D were associated with UTIs in girls, but we did not see any correlation with the recurrence of infection at one-year follow-up. Conclusion: Vitamin D deficiency is common and may prove to be a risk factor for UTIs especially in girls. We hypothesise that adequate supplementation with vitamin D may become a way to prevent first-time UTIs.

Detaljer

Författare
  • V. Georgieva
  • W. Kamolvit
  • M. Herthelius
  • P. Lüthje
  • A. Brauner
  • M. Chromek
Enheter & grupper
Externa organisationer
  • Karolinska University Hospital
  • Karolinska Institute
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Pediatrik
  • Näringslära

Nyckelord

Originalspråkengelska
Sidor (från-till)551-556
TidskriftActa Paediatrica, International Journal of Paediatrics
Volym108
Utgivningsnummer3
Tidigt onlinedatum2018 jul 13
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa