Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.

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Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40.


  • Elisabet Wirfält
  • D Midthune
  • J Reedy
  • P Mitrou
  • A Flood
  • A F Subar
  • M Leitzmann
  • T Mouw
  • A R Hollenbeck
  • A Schatzkin
  • V Kipnis
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Näringslära
Sidor (från-till)707-717
TidskriftEuropean Journal of Clinical Nutrition
StatusPublished - 2009
Peer review utfördJa