Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.

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Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study. / Wirfält, Elisabet; Midthune, D; Reedy, J; Mitrou, P; Flood, A; Subar, A F; Leitzmann, M; Mouw, T; Hollenbeck, A R; Schatzkin, A; Kipnis, V.

I: European Journal of Clinical Nutrition, Vol. 63, 2009, s. 707-717.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Wirfält, E, Midthune, D, Reedy, J, Mitrou, P, Flood, A, Subar, AF, Leitzmann, M, Mouw, T, Hollenbeck, AR, Schatzkin, A & Kipnis, V 2009, 'Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.', European Journal of Clinical Nutrition, vol. 63, s. 707-717. https://doi.org/10.1038/ejcn.2008.40

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Wirfält, Elisabet ; Midthune, D ; Reedy, J ; Mitrou, P ; Flood, A ; Subar, A F ; Leitzmann, M ; Mouw, T ; Hollenbeck, A R ; Schatzkin, A ; Kipnis, V. / Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study. I: European Journal of Clinical Nutrition. 2009 ; Vol. 63. s. 707-717.

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TY - JOUR

T1 - Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.

AU - Wirfält, Elisabet

AU - Midthune, D

AU - Reedy, J

AU - Mitrou, P

AU - Flood, A

AU - Subar, A F

AU - Leitzmann, M

AU - Mouw, T

AU - Hollenbeck, A R

AU - Schatzkin, A

AU - Kipnis, V

PY - 2009

Y1 - 2009

N2 - Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40.

AB - Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40.

U2 - 10.1038/ejcn.2008.40

DO - 10.1038/ejcn.2008.40

M3 - Article

VL - 63

SP - 707

EP - 717

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 1476-5640

ER -