Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus. / Sluik, Diewertje; Boeing, Heiner; Montonen, Jukka; Pischon, Tobias; Kaaks, Rudolf; Teucher, Birgit; Tjonneland, Anne; Halkjaer, Jytte; Berentzen, Tina L.; Overvad, Kim; Arriola, Larraitz; Ardanaz, Eva; Bendinelli, Benedetta; Grioni, Sara; Tumino, Rosario; Sacerdote, Carlotta; Mattiello, Amalia; Spijkerman, Annemieke M. W.; van der A, Daphne L.; Beulens, Joline W.; van der Schouw, Yvonne T.; Nilsson, Peter; Hedblad, Bo; Rolandsson, Olov; Franks, Paul; Noethlings, Ute.

I: American Journal of Epidemiology, Vol. 174, Nr. 1, 2011, s. 22-34.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Sluik, D, Boeing, H, Montonen, J, Pischon, T, Kaaks, R, Teucher, B, Tjonneland, A, Halkjaer, J, Berentzen, TL, Overvad, K, Arriola, L, Ardanaz, E, Bendinelli, B, Grioni, S, Tumino, R, Sacerdote, C, Mattiello, A, Spijkerman, AMW, van der A, DL, Beulens, JW, van der Schouw, YT, Nilsson, P, Hedblad, B, Rolandsson, O, Franks, P & Noethlings, U 2011, 'Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus', American Journal of Epidemiology, vol. 174, nr. 1, s. 22-34. https://doi.org/10.1093/aje/kwr048

APA

Sluik, D., Boeing, H., Montonen, J., Pischon, T., Kaaks, R., Teucher, B., ... Noethlings, U. (2011). Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus. American Journal of Epidemiology, 174(1), 22-34. https://doi.org/10.1093/aje/kwr048

CBE

Sluik D, Boeing H, Montonen J, Pischon T, Kaaks R, Teucher B, Tjonneland A, Halkjaer J, Berentzen TL, Overvad K, Arriola L, Ardanaz E, Bendinelli B, Grioni S, Tumino R, Sacerdote C, Mattiello A, Spijkerman AMW, van der A DL, Beulens JW, van der Schouw YT, Nilsson P, Hedblad B, Rolandsson O, Franks P, Noethlings U. 2011. Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus. American Journal of Epidemiology. 174(1):22-34. https://doi.org/10.1093/aje/kwr048

MLA

Vancouver

Author

Sluik, Diewertje ; Boeing, Heiner ; Montonen, Jukka ; Pischon, Tobias ; Kaaks, Rudolf ; Teucher, Birgit ; Tjonneland, Anne ; Halkjaer, Jytte ; Berentzen, Tina L. ; Overvad, Kim ; Arriola, Larraitz ; Ardanaz, Eva ; Bendinelli, Benedetta ; Grioni, Sara ; Tumino, Rosario ; Sacerdote, Carlotta ; Mattiello, Amalia ; Spijkerman, Annemieke M. W. ; van der A, Daphne L. ; Beulens, Joline W. ; van der Schouw, Yvonne T. ; Nilsson, Peter ; Hedblad, Bo ; Rolandsson, Olov ; Franks, Paul ; Noethlings, Ute. / Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus. I: American Journal of Epidemiology. 2011 ; Vol. 174, Nr. 1. s. 22-34.

RIS

TY - JOUR

T1 - Associations Between General and Abdominal Adiposity and Mortality in Individuals With Diabetes Mellitus

AU - Sluik, Diewertje

AU - Boeing, Heiner

AU - Montonen, Jukka

AU - Pischon, Tobias

AU - Kaaks, Rudolf

AU - Teucher, Birgit

AU - Tjonneland, Anne

AU - Halkjaer, Jytte

AU - Berentzen, Tina L.

AU - Overvad, Kim

AU - Arriola, Larraitz

AU - Ardanaz, Eva

AU - Bendinelli, Benedetta

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Mattiello, Amalia

AU - Spijkerman, Annemieke M. W.

AU - van der A, Daphne L.

AU - Beulens, Joline W.

AU - van der Schouw, Yvonne T.

AU - Nilsson, Peter

AU - Hedblad, Bo

AU - Rolandsson, Olov

AU - Franks, Paul

AU - Noethlings, Ute

PY - 2011

Y1 - 2011

N2 - Individuals with diabetes mellitus are advised to achieve a healthy weight to prevent complications. However, fat mass distribution has hardly been investigated as a risk factor for diabetes complications. The authors studied associations between body mass index, waist circumference, waist/hip ratio, and waist/height ratio and mortality among individuals with diabetes mellitus. Within the European Prospective Investigation into Cancer and Nutrition, a subcohort was defined as 5,435 individuals with a confirmed self-report of diabetes mellitus at baseline in 1992-2000. Participants were aged 57.3 (standard deviation, 6.3) years, 54% were men, the median diabetes duration was 4.6 (interquartile range, 2.0-9.8) years, and 22% of the participants used insulin. Body mass index, as indicator of general obesity, was not associated with higher mortality, whereas all measurements of abdominal obesity showed a positive association. Associations generally were slightly weaker in women. The strongest association was observed for waist/height ratio: In the fifth quintile, the hazard rate ratio was 1.88 (95% confidence interval: 1.33, 2.65) for men and 2.46 (95% confidence interval: 1.46, 4.14) for women. Measurements of abdominal, but not general, adiposity were associated with higher mortality in diabetic individuals. The waist/height ratio showed the strongest association. Respective indicators might be investigated in risk prediction models.

AB - Individuals with diabetes mellitus are advised to achieve a healthy weight to prevent complications. However, fat mass distribution has hardly been investigated as a risk factor for diabetes complications. The authors studied associations between body mass index, waist circumference, waist/hip ratio, and waist/height ratio and mortality among individuals with diabetes mellitus. Within the European Prospective Investigation into Cancer and Nutrition, a subcohort was defined as 5,435 individuals with a confirmed self-report of diabetes mellitus at baseline in 1992-2000. Participants were aged 57.3 (standard deviation, 6.3) years, 54% were men, the median diabetes duration was 4.6 (interquartile range, 2.0-9.8) years, and 22% of the participants used insulin. Body mass index, as indicator of general obesity, was not associated with higher mortality, whereas all measurements of abdominal obesity showed a positive association. Associations generally were slightly weaker in women. The strongest association was observed for waist/height ratio: In the fifth quintile, the hazard rate ratio was 1.88 (95% confidence interval: 1.33, 2.65) for men and 2.46 (95% confidence interval: 1.46, 4.14) for women. Measurements of abdominal, but not general, adiposity were associated with higher mortality in diabetic individuals. The waist/height ratio showed the strongest association. Respective indicators might be investigated in risk prediction models.

KW - adiposity

KW - body mass index

KW - diabetes complications

KW - diabetes mellitus

KW - mortality

KW - waist circumference

KW - waist-hip ratio

U2 - 10.1093/aje/kwr048

DO - 10.1093/aje/kwr048

M3 - Article

VL - 174

SP - 22

EP - 34

JO - American journal of hygiene

T2 - American journal of hygiene

JF - American journal of hygiene

SN - 0002-9262

IS - 1

ER -