Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and monoamine metabolite concentrations in cerebrospinal fluid

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Detaljer

Författare
  • Kristina Annerbrink
  • Erik G. Jonsson
  • Marie Olsson
  • Staffan Nilsson
  • Goran C. Sedvall
  • Henrik Anckarsäter
  • Elias Eriksson
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Psykiatri

Nyckelord

Originalspråkengelska
Sidor (från-till)231-234
TidskriftPsychiatry Research
Volym179
Utgivningsnummer2
StatusPublished - 2010
PublikationskategoriForskning
Peer review utfördJa