Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study. / Xu, Yiyi; Wahlberg, Karin; Love, Tanzy M.; Watson, Gene E.; Yeates, Alison J.; Mulhern, Maria S.; McSorley, Emeir M.; Strain, J. J.; Davidson, Philip W.; Shamlaye, Conrad F.; Rand, Matthew D.; Myers, G. J.; van Wijngaarden, Edwin; Broberg, Karin.

I: Environment International, Vol. 124, 2019, s. 278-283.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Xu, Y, Wahlberg, K, Love, TM, Watson, GE, Yeates, AJ, Mulhern, MS, McSorley, EM, Strain, JJ, Davidson, PW, Shamlaye, CF, Rand, MD, Myers, GJ, van Wijngaarden, E & Broberg, K 2019, 'Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study', Environment International, vol. 124, s. 278-283. https://doi.org/10.1016/j.envint.2019.01.019

APA

CBE

MLA

Vancouver

Author

Xu, Yiyi ; Wahlberg, Karin ; Love, Tanzy M. ; Watson, Gene E. ; Yeates, Alison J. ; Mulhern, Maria S. ; McSorley, Emeir M. ; Strain, J. J. ; Davidson, Philip W. ; Shamlaye, Conrad F. ; Rand, Matthew D. ; Myers, G. J. ; van Wijngaarden, Edwin ; Broberg, Karin. / Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study. I: Environment International. 2019 ; Vol. 124. s. 278-283.

RIS

TY - JOUR

T1 - Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study

AU - Xu, Yiyi

AU - Wahlberg, Karin

AU - Love, Tanzy M.

AU - Watson, Gene E.

AU - Yeates, Alison J.

AU - Mulhern, Maria S.

AU - McSorley, Emeir M.

AU - Strain, J. J.

AU - Davidson, Philip W.

AU - Shamlaye, Conrad F.

AU - Rand, Matthew D.

AU - Myers, G. J.

AU - van Wijngaarden, Edwin

AU - Broberg, Karin

PY - 2019

Y1 - 2019

N2 - Background: Fish contains methylmercury (MeHg) which can cause oxidative stress and neurodevelopmental toxicity at sufficiently high doses. Fish also contains polyunsaturated fatty acids (PUFA) which have both antioxidant (n-3) and oxidant (n-6) properties. Mitochondrial DNA (mtDNA) is sensitive to oxidative stress but has not been previously studied in relation to MeHg exposure or PUFA status. Objective: To investigate the associations between MeHg exposure and PUFA status during pregnancy with relative mitochondrial DNA copy number (RmtDNAcn) in mothers and their newborns. Methods: In total, 1488 mother-child pairs from the Seychelles Child Development Study Nutrition Cohort 2 were included in this study. Total Hg was measured in maternal blood collected at 28 weeks’ gestation, maternal hair at delivery, and in fetal cord blood. PUFA (n-3 and n-6) were measured only in maternal blood. RmtDNAcn was measured by qPCR in both maternal and cord blood. Results: Increasing maternal blood Hg (β = 0.001, 95%CI: 0.000, 0.002) and n-3 PUFA concentrations (β = 0.183, 95%CI: 0.048, 0.317) were associated with higher maternal RmtDNAcn. Increasing maternal n-6 PUFA (β = −0.103, 95%CI: −0.145, −0.062) and n-6/n-3 ratio (β = −0.011, 95%CI: −0.017, −0.004) were associated with lower maternal RmtDNAcn. Increasing fetal cord blood Hg was associated with lower fetal RmtDNAcn (β = −0.002, 95%CI: −0.004, −0.000). Neither maternal blood Hg nor PUFA status was associated with fetal RmtDNAcn. Conclusions: Our findings suggest that MeHg and PUFA may influence mitochondrial homeostasis although the magnitude of these associations are small. Future studies should confirm the findings and explore the underlying mechanisms.

AB - Background: Fish contains methylmercury (MeHg) which can cause oxidative stress and neurodevelopmental toxicity at sufficiently high doses. Fish also contains polyunsaturated fatty acids (PUFA) which have both antioxidant (n-3) and oxidant (n-6) properties. Mitochondrial DNA (mtDNA) is sensitive to oxidative stress but has not been previously studied in relation to MeHg exposure or PUFA status. Objective: To investigate the associations between MeHg exposure and PUFA status during pregnancy with relative mitochondrial DNA copy number (RmtDNAcn) in mothers and their newborns. Methods: In total, 1488 mother-child pairs from the Seychelles Child Development Study Nutrition Cohort 2 were included in this study. Total Hg was measured in maternal blood collected at 28 weeks’ gestation, maternal hair at delivery, and in fetal cord blood. PUFA (n-3 and n-6) were measured only in maternal blood. RmtDNAcn was measured by qPCR in both maternal and cord blood. Results: Increasing maternal blood Hg (β = 0.001, 95%CI: 0.000, 0.002) and n-3 PUFA concentrations (β = 0.183, 95%CI: 0.048, 0.317) were associated with higher maternal RmtDNAcn. Increasing maternal n-6 PUFA (β = −0.103, 95%CI: −0.145, −0.062) and n-6/n-3 ratio (β = −0.011, 95%CI: −0.017, −0.004) were associated with lower maternal RmtDNAcn. Increasing fetal cord blood Hg was associated with lower fetal RmtDNAcn (β = −0.002, 95%CI: −0.004, −0.000). Neither maternal blood Hg nor PUFA status was associated with fetal RmtDNAcn. Conclusions: Our findings suggest that MeHg and PUFA may influence mitochondrial homeostasis although the magnitude of these associations are small. Future studies should confirm the findings and explore the underlying mechanisms.

KW - Mercury

KW - Methylmercury

KW - Mitochondrial DNA

KW - Polyunsaturated fatty acids

U2 - 10.1016/j.envint.2019.01.019

DO - 10.1016/j.envint.2019.01.019

M3 - Article

VL - 124

SP - 278

EP - 283

JO - Environmental International

T2 - Environmental International

JF - Environmental International

SN - 1873-6750

ER -