ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability.

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Abstract

Autophagy has emerged as a cell survival mechanism critical for cellular homeostasis, which may play a protective role in atherosclerosis. ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. However, it is unknown whether ATG16L1 is involved in atherosclerosis. Our aim was to analyze ATG16L1 expression in carotid atherosclerotic plaques in relation to markers of plaque vulnerability.

Detaljer

Författare
  • Joelle Magné
  • Peter Gustafsson
  • Hong Jin
  • Lars Maegdefessel
  • Kjell Hultenby
  • Annika Wernerson
  • Per Eriksson
  • Anders Franco-Cereceda
  • Petri T Kovanen
  • Isabel Goncalves
  • Ewa Ehrenborg
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Originalspråkengelska
Sidor (från-till)1226-1235
TidskriftArteriosclerosis, Thrombosis and Vascular Biology
Volym35
Utgivningsnummer5
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa