Atherogenic effects of upper respiratory infections and passive smoking in children with type 1 diabetes mellitus
Forskningsoutput: Tidskriftsbidrag › Publicerat konferensabstract
Background: Infection could contribute to atherosclerosis. Several experimental animal studies have suggested possible cumulative adverse effects ofrepeated infections on arterial wall. Viral infections in the upper airways are more common in diabetic patients. Methods: Common carotid artery compliance (CAC) and stiftness index (SI) were assessed by external ultrasound in 70 children (mean age 14.9) with type 1 diabetes mellitus. The number of upper respiratory tract infections (URTI) experienced during the past year was assessed by questionnaire. Household tobacco smoke exposure (TSE) was assessed by both questionnaire (nr of cigarettes smoked/day) and plasma cotinine. Plasma lipids, CRP, and Hblac were measured. Results: CAC was decreased while SI was increased in children with frequent URTI (more than 4 per year; n=18) as compared with the remaining children (p<0.05 for both). Plasma cotinine was higher in children with frequent URTI than in the remaining children (34-2 vs 594-29 ng/ml, p<0.01). The number of cigarettes/day correlated with TC/HDL (p=0.001, r=0.5) and LDL/HDL (p=0,001, r=0.4) ratios and with CRP (p<0.05, r=0.2). In a multivariate model, the number of URTI/past year and HbA1C were independent predictors of the decrease in CAC (r=-0.3 and -0.4, respectively; p<0.05 for both). Conclusion: Recurrent viral infections in the upper airways seem to have cumulative deleterious effects on the arterial elasticity in diabetic children.Passive smoking could be an important link. Funding: Petru Liuba (principal investigator) received a clinical scientist faculty award from FAMRI (FL, USA).
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Status||Published - 2006 jun|
|Peer review utförd||Ja|
|Evenemang||14th Meeting of the International Society of Atherosclerosis - Rome, Italien|
Varaktighet: 2006 jun 18 → 2006 jun 22