Augmenting Glioblastoma Chemotherapy with Polymers

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Chemotherapeutics are vital for treating brain tumors such as glioblastoma, an aggressive and prolific cancer predominantly treated with DNA alkylating agents. The efficacy of antiglioblastoma drugs, such as temozolomide, is limited by their rapid clearance and instability under normal physiological conditions. Both local and systemic polymer-based therapeutics have shown promise for treating many cancers, and as such there is a growing interest in applying polymer techniques to augment the efficacy and stability of glioblastoma chemotherapeutics. Notably, brain tumor chemotherapy presents unique challenges and will require tailored delivery systems to develop markedly improved treatments.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Massachusetts
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Läkemedelskemi
  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)8-10
Antal sidor3
TidskriftACS Chemical Neuroscience
Volym9
Utgivningsnummer1
StatusPublished - 2018 jan 17
PublikationskategoriForskning
Peer review utfördJa