Automated Operant Assessments of Huntington's Disease Mouse Models

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Cardiff University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)143-162
Antal sidor20
TidskriftMethods in molecular biology (Clifton, N.J.)
Volym1780
StatusPublished - 2018
PublikationskategoriForskning
Peer review utfördJa