Automated Operant Assessments of Huntington's Disease Mouse Models

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Automated Operant Assessments of Huntington's Disease Mouse Models. / Yhnell, Emma; Heuer, Andreas.

I: Methods in molecular biology (Clifton, N.J.), Vol. 1780, 2018, s. 143-162.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Automated Operant Assessments of Huntington's Disease Mouse Models

AU - Yhnell, Emma

AU - Heuer, Andreas

PY - 2018

Y1 - 2018

N2 - Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.

AB - Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.

KW - 9-Hole box

KW - Behavior

KW - Cognition

KW - Huntington’s disease

KW - Knockin

KW - Mouse model

KW - Operant

KW - Skinner box

KW - Touch screen

KW - Transgenic

U2 - 10.1007/978-1-4939-7825-0_8

DO - 10.1007/978-1-4939-7825-0_8

M3 - Article

C2 - 29856018

AN - SCOPUS:85058487381

VL - 1780

SP - 143

EP - 162

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1940-6029

ER -