Axillary Web Syndrome: Evidence for Lymphatic Origin with Thrombosis

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Background: The axillary web syndrome (AWS) occurs in the axilla and on the frontal side of the upper arm and sometimes along the forearm to the thumb. The cord is painful, particularly on movement, and can therefore be very distressing for the patient. Although the phenomenon has been examined and discussed for decades, no evidence for the origin has been found until now. The aim of this study was to perform a histopathologic analysis of cords taken between 1996 and 1998 in the Surgical Clinic, Skane University Hospital, Lund, Sweden. Methods and Results: In seven patients, biopsies of the AWS cords were obtained 4-5 weeks after axillary node surgery for breast cancer and examined with standard hematoxylin and eosin and D2-40 (lymphatic endothelial cell) staining. In one biopsy, there was a dilated vessel with a thickened wall, which was confirmed by D2-40 immunostaining to represent a lymphatic vessel. The lumen was occluded by organized thrombus, within which new vessels were being formed, indicating recanalization. In two other biopsies, similar lymphatic vessels with thickened walls were present, although the lumen of the vessels was not visualized in the planes of the section. The other four biopsies do not show specific features. Conclusion: Although only one case, this is the first pathological evidence of thrombosis within a confirmed lymphatic vessel from a case of cording. We propose that the axillary cord represents lymphatic vessel thrombosis. Recanalization of the thrombus may eventually restore lymphatic flow consistent with the transient nature of the condition.


Enheter & grupper
Externa organisationer
  • St George's Hospital, London
  • Regional Laboratories Region Skåne
  • Skåne University Hospital
  • St George's, University of London

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Kardiologi
  • Kirurgi
Sidor (från-till)329-332
TidskriftLymphatic Research and Biology
Utgåva nummer4
Tidigt onlinedatum2019 dec 27
StatusPublished - 2020
Peer review utfördJa