Backbone resonance assignment of Staphylococcal Enterotoxin H

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Abstract

The staphylococcal enterotoxin H (SEH; 217 aa, 25 kD) belongs to a family of superantigens that cause a massive immune response upon simultaneous binding to the T cell receptor (TCR) and the major histocompatibility complex class II. The SEH-TCR interaction is weak and amenable to studies using NMR methodology. Essentially, 2 mg of U{2H, 13C,15N}-labeled SEH was used for the complete sequential backbone assignment of SEH at 900 MHz. The protein secondary structure inferred from the chemical shift index (C α and Cβ) is in very good agreement with the secondary structure elements of the X-ray structure.

Detaljer

Författare
Externa organisationer
  • Göteborgs universitet
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)1-4
TidskriftBiomolecular NMR Assignments
Volym4
Utgåva nummer1
StatusPublished - 2010 apr
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa