Bacterial Hydrolysis of Host Glycoproteins - Powerful Protein Modification and Efficient Nutrient Acquisition.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dramatic effects on glycoprotein function and, thereby, be beneficial for the bacteria in different ways. This review gives an introduction to the expanding field of extracellular glycosidases from bacterial pathogens with activity on host glycoproteins, describes some known and proposed consequences for the host and the bacteria and discusses some evolutionary and regulatory aspects of bacterial glycosidases.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
Originalspråkengelska
Sidor (från-till)121-131
TidskriftJournal of Innate Immunity
Volym4
Utgivningsnummer2
StatusPublished - 2012
PublikationskategoriForskning
Peer review utfördJa

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