Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial

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Bibtex

@article{a5a99b51cd94461c803ed8b442bb90f4,
title = "Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial",
abstract = "The efficacy of bendamustine versus chlorambucil in a phase III trial of previously untreated patients with Binet stage B/C chronic lymphocytic leukaemia (CLL) was re-evaluated after a median observation time of 54months in May 2010. Overall survival (OS) was analysed for the first time. At follow-up, investigator-assessed complete response (CR) rate (21.0{\%} vs 10.8{\%}), median progression-free survival (21.2 vs 8.8months; P<0.0001; hazard ratio 2.83) and time to next treatment (31.7 vs 10.1months; P<0.0001) were improved for bendamustine over chlorambucil. OS was not different between groups for all patients or those =65years, >65 years, responders and non-responders. However, patients with objective response or a CR experienced a significantly longer OS than non-responders or those without a CR. Significantly more patients on chlorambucil progressed to second/further lines of treatment compared with those on bendamustine (78.3{\%} vs 63.6{\%}; P=0.004). The benefits of bendamustine over chlorambucil were achieved without reducing quality of life. In conclusion, bendamustine is significantly more effective than chlorambucil in previously untreated CLL patients, with the achievement of a CR or objective response appearing to prolong OS. Bendamustine should be considered as a preferred first-line option over chlorambucil for CLL patients ineligible for fludarabine, cyclophosphamide and rituximab.",
keywords = "bendamustine, chlorambucil, chronic lymphocytic leukaemia, complete, response, overall survival",
author = "Knauf, {Wolfgang U.} and Toshko Lissitchkov and Ali Aldaoud and Liberati, {Anna M.} and Javier Loscertales and Raoul Herbrecht and Gunnar Juliusson and Gerhard Postner and Liana Gercheva and Stefan Goranov and Martin Becker and Hans-Joerg Fricke and Francoise Huguet and {Del Giudice}, Ilaria and Peter Klein and Karlheinz Merkle and Marco Montillo",
year = "2012",
doi = "10.1111/bjh.12000",
language = "English",
volume = "159",
pages = "67--77",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Federation of European Neuroscience Societies and Blackwell Publishing Ltd",
number = "1",

}