Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

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Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale. / Aqueveque, Pedro; Leonardo Cespedes, Carlos; Becerra, Jose; Davila, Marcelo; Sterner, Olov.

I: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences, Vol. 70, Nr. 3-4, 2015, s. 97-102.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Aqueveque, Pedro ; Leonardo Cespedes, Carlos ; Becerra, Jose ; Davila, Marcelo ; Sterner, Olov. / Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale. I: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. 2015 ; Vol. 70, Nr. 3-4. s. 97-102.

RIS

TY - JOUR

T1 - Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

AU - Aqueveque, Pedro

AU - Leonardo Cespedes, Carlos

AU - Becerra, Jose

AU - Davila, Marcelo

AU - Sterner, Olov

PY - 2015

Y1 - 2015

N2 - Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.

AB - Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.

KW - antibacterial activity

KW - MIC

KW - MS-3

KW - Stereum rameale

KW - vibralactone

U2 - 10.1515/znc-2015-5005

DO - 10.1515/znc-2015-5005

M3 - Article

VL - 70

SP - 97

EP - 102

JO - Zeitschrift fur Naturforschung - Section C Journal of Biosciences

T2 - Zeitschrift fur Naturforschung - Section C Journal of Biosciences

JF - Zeitschrift fur Naturforschung - Section C Journal of Biosciences

SN - 0939-5075

IS - 3-4

ER -