Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves.

Detaljer

Författare
  • J Ekstrom
  • Lars Malmberg
  • A Wallin
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Urologi och njurmedicin
Originalspråkengelska
Sidor (från-till)86-89
TidskriftPharmacology and Toxicology
Volym60
Utgåva nummer2
StatusPublished - 1987
PublikationskategoriForskning
Peer review utfördJa