Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies

Forskningsoutput: TidskriftsbidragÖversiktsartikel


Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.


  • Lars Nyberg
  • Carl Johan Boraxbekk
  • Daniel Eriksson Sörman
  • Patrik Hansson
  • Agneta Herlitz
  • Karolina Kauppi
  • Jessica K. Ljungberg
  • Hugo Lövheim
  • Anders Lundquist
  • Annelie Nordin Adolfsson
  • Anna Oudin
  • Sara Pudas
  • Michael Rönnlund
  • Mikael Stiernstedt
  • Anna Sundström
  • Rolf Adolfsson
Enheter & grupper
Externa organisationer
  • Umeå University
  • Hvidovre Hospital
  • Bispebjerg Hospital
  • Luleå University of Technology
  • Karolinska Institute

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi


TidskriftAgeing Research Reviews
StatusPublished - 2020
Peer review utfördJa