Biomarkers for equine joint injury and osteoarthritis

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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Biomarkers for equine joint injury and osteoarthritis. / McIlwraith, C. Wayne; Kawcak, Christopher E.; Frisbie, David D.; Little, Christopher B.; Clegg, Peter D.; Peffers, Mandy J.; Karsdal, Morten A.; Ekman, Stina; Laverty, Sheila; Slayden, Richard A.; Sandell, Linda J.; Lohmander, L. S.; Kraus, Virginia B.

I: Journal of Orthopaedic Research, Vol. 36, Nr. 3, 01.03.2018, s. 823-831.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

McIlwraith, CW, Kawcak, CE, Frisbie, DD, Little, CB, Clegg, PD, Peffers, MJ, Karsdal, MA, Ekman, S, Laverty, S, Slayden, RA, Sandell, LJ, Lohmander, LS & Kraus, VB 2018, 'Biomarkers for equine joint injury and osteoarthritis', Journal of Orthopaedic Research, vol. 36, nr. 3, s. 823-831. https://doi.org/10.1002/jor.23738

APA

McIlwraith, C. W., Kawcak, C. E., Frisbie, D. D., Little, C. B., Clegg, P. D., Peffers, M. J., ... Kraus, V. B. (2018). Biomarkers for equine joint injury and osteoarthritis. Journal of Orthopaedic Research, 36(3), 823-831. https://doi.org/10.1002/jor.23738

CBE

McIlwraith CW, Kawcak CE, Frisbie DD, Little CB, Clegg PD, Peffers MJ, Karsdal MA, Ekman S, Laverty S, Slayden RA, Sandell LJ, Lohmander LS, Kraus VB. 2018. Biomarkers for equine joint injury and osteoarthritis. Journal of Orthopaedic Research. 36(3):823-831. https://doi.org/10.1002/jor.23738

MLA

Vancouver

McIlwraith CW, Kawcak CE, Frisbie DD, Little CB, Clegg PD, Peffers MJ et al. Biomarkers for equine joint injury and osteoarthritis. Journal of Orthopaedic Research. 2018 mar 1;36(3):823-831. https://doi.org/10.1002/jor.23738

Author

McIlwraith, C. Wayne ; Kawcak, Christopher E. ; Frisbie, David D. ; Little, Christopher B. ; Clegg, Peter D. ; Peffers, Mandy J. ; Karsdal, Morten A. ; Ekman, Stina ; Laverty, Sheila ; Slayden, Richard A. ; Sandell, Linda J. ; Lohmander, L. S. ; Kraus, Virginia B. / Biomarkers for equine joint injury and osteoarthritis. I: Journal of Orthopaedic Research. 2018 ; Vol. 36, Nr. 3. s. 823-831.

RIS

TY - JOUR

T1 - Biomarkers for equine joint injury and osteoarthritis

AU - McIlwraith, C. Wayne

AU - Kawcak, Christopher E.

AU - Frisbie, David D.

AU - Little, Christopher B.

AU - Clegg, Peter D.

AU - Peffers, Mandy J.

AU - Karsdal, Morten A.

AU - Ekman, Stina

AU - Laverty, Sheila

AU - Slayden, Richard A.

AU - Sandell, Linda J.

AU - Lohmander, L. S.

AU - Kraus, Virginia B.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equine and human musculoskeletal biomarkers to enable cross-disciplinary exchange and improve knowledge in both. Detailed proceedings with strategic planning was written, added to, edited and referenced to develop this manuscript. The most recent information from work in equine and human osteoarthritic biomarkers was accumulated, including the use of personalized healthcare to stratify OA phenotypes, transcriptome analysis of anterior cruciate ligament (ACL) and meniscal injuries in the human knee. The spectrum of “wet” biomarker assays that are antibody based that have achieved usefulness in both humans and horses, imaging biomarkers and the role they can play in equine and human OA was discussed. Prediction of musculoskeletal injury in the horse remains a challenge, and the potential usefulness of spectroscopy, metabolomics, proteomics, and development of biobanks to classify biomarkers in different stages of equine and human OA were reviewed. The participants concluded that new information and studies in equine musculoskeletal biomarkers have potential translational value for humans and vice versa. OA is equally important in humans and horses, and the welfare issues associated with catastrophic musculoskeletal injury in horses add further emphasis to the need for good validated biomarkers in the horse.

AB - We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equine and human musculoskeletal biomarkers to enable cross-disciplinary exchange and improve knowledge in both. Detailed proceedings with strategic planning was written, added to, edited and referenced to develop this manuscript. The most recent information from work in equine and human osteoarthritic biomarkers was accumulated, including the use of personalized healthcare to stratify OA phenotypes, transcriptome analysis of anterior cruciate ligament (ACL) and meniscal injuries in the human knee. The spectrum of “wet” biomarker assays that are antibody based that have achieved usefulness in both humans and horses, imaging biomarkers and the role they can play in equine and human OA was discussed. Prediction of musculoskeletal injury in the horse remains a challenge, and the potential usefulness of spectroscopy, metabolomics, proteomics, and development of biobanks to classify biomarkers in different stages of equine and human OA were reviewed. The participants concluded that new information and studies in equine musculoskeletal biomarkers have potential translational value for humans and vice versa. OA is equally important in humans and horses, and the welfare issues associated with catastrophic musculoskeletal injury in horses add further emphasis to the need for good validated biomarkers in the horse.

KW - biomarkers

KW - osteoarthritis

KW - traumatic arthritis

U2 - 10.1002/jor.23738

DO - 10.1002/jor.23738

M3 - Review article

VL - 36

SP - 823

EP - 831

JO - Journal of Orthopaedic Research

T2 - Journal of Orthopaedic Research

JF - Journal of Orthopaedic Research

SN - 1554-527X

IS - 3

ER -