Biomimetic spinning of artificial spider silk from a chimeric minispidroin

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.

Detaljer

Författare
  • Marlene Andersson
  • Qiupin Jia
  • Ana Abella
  • Xiau Yeen Lee
  • Michael Landreh
  • Pasi Purhonen
  • Hans Hebert
  • Maria Tenje
  • Carol V. Robinson
  • Qing Meng
  • Gustavo R. Plaza
  • Jan Johansson
  • Anna Rising
Enheter & grupper
Externa organisationer
  • Swedish University of Agricultural Sciences
  • University of Oxford
  • Karolinska Institute
  • KTH Royal Institute of Technology
  • Uppsala universitet, Historiska institutionen
  • Donghua University
  • Technical University of Madrid
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biomaterialvetenskap
Originalspråkengelska
Sidor (från-till)262-264
Antal sidor3
TidskriftNature Chemical Biology
Volym13
Utgivningsnummer3
StatusPublished - 2017 mar 1
PublikationskategoriForskning
Peer review utfördJa