Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid.

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Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid. / Shanker, Shiva; Grey, Carl; Adlercreutz, Patrick.

I: Journal of Biotechnology, Vol. 157, Nr. 2, 2012, s. 344-349.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid.

AU - Shanker, Shiva

AU - Grey, Carl

AU - Adlercreutz, Patrick

PY - 2012

Y1 - 2012

N2 - Chemo-enzymatic synthesis of six esters of natural phenolics and α-lipoic acid was carried to produce novel compounds with potential bioactivity. The synthetic route was mild, simple, and efficient with satisfactory yields. The synthesized compounds were screened for antioxidant activities. The prepared derivatives exhibited very good antioxidant activities as determined by DPPH radical scavenging assay and inhibition of lipid oxidation in fish oil emulsion system. Among the prepared derivatives, three compounds exhibited radical scavenging activity similar to the reference antioxidants, BHT and alpha-tocopherol in the DPPH radical scavenging assay, where as in fish oil emulsion system, two derivatives showed activity, which was similar to the reference antioxidants.

AB - Chemo-enzymatic synthesis of six esters of natural phenolics and α-lipoic acid was carried to produce novel compounds with potential bioactivity. The synthetic route was mild, simple, and efficient with satisfactory yields. The synthesized compounds were screened for antioxidant activities. The prepared derivatives exhibited very good antioxidant activities as determined by DPPH radical scavenging assay and inhibition of lipid oxidation in fish oil emulsion system. Among the prepared derivatives, three compounds exhibited radical scavenging activity similar to the reference antioxidants, BHT and alpha-tocopherol in the DPPH radical scavenging assay, where as in fish oil emulsion system, two derivatives showed activity, which was similar to the reference antioxidants.

KW - Lipase

KW - Synthesis

KW - Antioxidant

KW - alpha-Lipoic acid

KW - Phenolics

U2 - 10.1016/j.jbiotec.2011.11.012

DO - 10.1016/j.jbiotec.2011.11.012

M3 - Article

VL - 157

SP - 344

EP - 349

JO - Journal of Biotechnology

T2 - Journal of Biotechnology

JF - Journal of Biotechnology

SN - 1873-4863

IS - 2

ER -