Bioreactor control using a probing feeding strategy and mid-ranging control

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Bioreactor control using a probing feeding strategy and mid-ranging control. / Velut, Stéphane; de Maré, Lena; Hagander, Per.

I: Control Engineering Practice, Vol. 15, Nr. 2, 2007, s. 135-147.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Bioreactor control using a probing feeding strategy and mid-ranging control

AU - Velut, Stéphane

AU - de Maré, Lena

AU - Hagander, Per

PY - 2007

Y1 - 2007

N2 - The paper presents a fed-batch fermentation technique for bioreactors operating close to their maximum oxygen transfer capacity. The method combines the advantages of the probing feeding strategy and the temperature limited fed-batch technique. When the maximum oxygen transfer capacity of the reactor is reached, the temperature is decreased to lower the oxygen demand. To achieve a good control of the dissolved oxygen a mid-ranging controller manipulating the stirrer speed and the temperature is used. The feeding strategy is analysed and it is also illustrated by simulations and an experiment. (c) 2006 Elsevier Ltd. All rights reserved.

AB - The paper presents a fed-batch fermentation technique for bioreactors operating close to their maximum oxygen transfer capacity. The method combines the advantages of the probing feeding strategy and the temperature limited fed-batch technique. When the maximum oxygen transfer capacity of the reactor is reached, the temperature is decreased to lower the oxygen demand. To achieve a good control of the dissolved oxygen a mid-ranging controller manipulating the stirrer speed and the temperature is used. The feeding strategy is analysed and it is also illustrated by simulations and an experiment. (c) 2006 Elsevier Ltd. All rights reserved.

KW - temperature

KW - mid-ranging

KW - control

KW - dissolved oxygen

KW - probing

KW - fermentation processes

KW - feeding strategy

U2 - 10.1016/j.conengprac.2006.05.009

DO - 10.1016/j.conengprac.2006.05.009

M3 - Article

VL - 15

SP - 135

EP - 147

JO - Control Engineering Practice

JF - Control Engineering Practice

SN - 0967-0661

IS - 2

ER -