Bivalent polyether ionophores: Synthesis and biological evaluation of C2-symmetric salinomycin dimers

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Abstract

Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Adam Mickiewicz University in Poznań
  • Polish Academy of Sciences
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biokemi och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)2396-2399
Antal sidor4
TidskriftTetrahedron Letters
Volym58
Utgivningsnummer24
StatusPublished - 2017
PublikationskategoriForskning
Peer review utfördJa