Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Karolinska Institute
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Artikelnummer1732
TidskriftCells
Volym9
Utgåva nummer7
StatusPublished - 2020
PublikationskategoriForskning
Peer review utfördJa