Blunted pubertal growth after leukemia: a new pattern of growth hormone insufficiency

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Growth, age at menarche and spontaneous GH secretion were studied in girls after treatment for acute lymphoblastic leukemia (ALL). These girls had normal prepubertal growth but subnormal pubertal growth. Mean final height was 1 SD less than expected before puberty. The average age at menarche was significantly lower than the normal mean for Swedish girls. The mean 24-hour GH secretion was severely blunted and there was no increase during puberty. We suggest that girls treated for ALL, including CNS irradiation, have a relative GH insufficiency which becomes clinically obvious only when the girls cannot respond to the increased demands for GH in puberty.

Detaljer

Författare
  • Christian Moëll
  • Stanislaw Garwicz
  • Ulf Westgren
  • Thomas Wiebe
  • K Albertsson-Wikland
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Pediatrik
Originalspråkengelska
Sidor (från-till)68-71
TidskriftHormone Research
Volym30
Utgåva nummer2-3
StatusPublished - 1988
PublikationskategoriForskning
Peer review utfördJa