Brain stem audiometry may supply markers for diagnostic and therapeutic control in psychiatry

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Brain stem audiometry may supply markers for diagnostic and therapeutic control in psychiatry. / Nielzén, Sören; Holmberg, Jens; Sköld, Mia; Nehlstedt, Sara.

I: Neuroscience Letters, Vol. 632, 2016, s. 163-168.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Nielzén, Sören ; Holmberg, Jens ; Sköld, Mia ; Nehlstedt, Sara. / Brain stem audiometry may supply markers for diagnostic and therapeutic control in psychiatry. I: Neuroscience Letters. 2016 ; Vol. 632. s. 163-168.

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TY - JOUR

T1 - Brain stem audiometry may supply markers for diagnostic and therapeutic control in psychiatry

AU - Nielzén, Sören

AU - Holmberg, Jens

AU - Sköld, Mia

AU - Nehlstedt, Sara

PY - 2016

Y1 - 2016

N2 - The purpose of the present study is to try an alternative way of analyzing the ABR (Auditory Brainstem Response). The stimuli were complex sounds (c-ABR) as used in earlier studies. It was further aimed at corroborating earlier findings that this method can discriminate several neuropsychiatric states. Forty healthy control subjects, 26 subjects with the diagnosis schizophrenia (Sz) and 33 with ADHD (Attention deficit hyperactivity disorder) were recruited for the study. The ABRs were recorded. The analysis was based on calculation of areas of significantly group different time spans in the waves. Both latency and amplitude were thereby influential. The spans of differences were quantified for each subject in relation to the total area of the curve which made comparisons balanced. The results showed highly significant differences between the study groups. The results are important for future work on identifying markers for neuropsychiatric clinical use. To reach that goal calls for more extensive studies than this preliminary one.

AB - The purpose of the present study is to try an alternative way of analyzing the ABR (Auditory Brainstem Response). The stimuli were complex sounds (c-ABR) as used in earlier studies. It was further aimed at corroborating earlier findings that this method can discriminate several neuropsychiatric states. Forty healthy control subjects, 26 subjects with the diagnosis schizophrenia (Sz) and 33 with ADHD (Attention deficit hyperactivity disorder) were recruited for the study. The ABRs were recorded. The analysis was based on calculation of areas of significantly group different time spans in the waves. Both latency and amplitude were thereby influential. The spans of differences were quantified for each subject in relation to the total area of the curve which made comparisons balanced. The results showed highly significant differences between the study groups. The results are important for future work on identifying markers for neuropsychiatric clinical use. To reach that goal calls for more extensive studies than this preliminary one.

KW - ADHD

KW - Auditory brainstem response

KW - Biomarker

KW - Brainstem

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84984996401&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2016.08.041

DO - 10.1016/j.neulet.2016.08.041

M3 - Article

C2 - 27581525

AN - SCOPUS:84984996401

VL - 632

SP - 163

EP - 168

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -