Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, secondary analysis was to identify candidate single nucleotide polymorphisms (SNP) from those associated with opioid receptors, signalling or pain modulation to identify any related to intensity of breathlessness while on opioids. This can help to inform prospective studies and potentially lead to better tailoring of opioid therapy for refractory breathlessness.

Detaljer

Författare
  • David C Currow
  • Stephen Quinn
  • Magnus Ekström
  • Stein Kaasa
  • Miriam J Johnson
  • Andrew A Somogyi
  • Päl Klepstad
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi
Originalspråkengelska
Artikelnummere006818
TidskriftBMJ Open
Volym5
Utgåva nummer5
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa

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