Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.

Detaljer

Författare
  • Borja Ibanez
  • Andrew E. Arai
  • Jeroen Bax
  • Colin Berry
  • Chiara Bucciarelli-Ducci
  • Pierre Croisille
  • Erica Dall'Armellina
  • Rohan Dharmakumar
  • Ingo Eitel
  • Rodrigo Fernández-Jiménez
  • Matthias G. Friedrich
  • David García-Dorado
  • Derek J. Hausenloy
  • Raymond J. Kim
  • Sebastian Kozerke
  • Christopher M. Kramer
  • Michael Salerno
  • Javier Sánchez-González
  • Javier Sanz
  • Valentin Fuster
Enheter & grupper
Externa organisationer
  • Centro Nacional de Investigaciones Cardiovasculares Carlos III
  • Hospital Fundación Jiménez Díaz
  • Aristotle University of Thessaloniki
  • National Heart Lung and Blood Institute
  • Leiden University Medical Centre
  • University of Bristol
  • University of Leeds
  • University of California, Los Angeles
  • German Centre for Cardiovascular Research
  • Icahn School of Medicine at Mount Sinai
  • McGill University
  • Heidelberg University
  • Autonomous University of Barcelona
  • National University of Singapore
  • University College London
  • Duke University Medical Center
  • ETH Zürich
  • University of Virginia Health System
  • Philips Healthcare Netherlands
  • University of Glasgow
  • University of Lyon
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk laboratorie- och mätteknik
  • Kardiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)238-256
Antal sidor19
TidskriftJournal of the American College of Cardiology
Volym74
Utgivningsnummer2
StatusPublished - 2019 jul 16
PublikationskategoriForskning
Peer review utfördJa