c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.

Detaljer

Författare
  • Matthew J Bush
  • Natalia Tschowri
  • Susan Schlimpert
  • Klas Flärdh
  • Mark J Buttner
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Utvecklingsbiologi
Originalspråkengelska
Sidor (från-till)749-760
TidskriftNature Reviews. Microbiology
Volym13
Utgåva nummer12
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa