Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone

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Bibtex

@article{6a43ee7174634b25a61293afc927940d,
title = "Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone",
abstract = "We investigated the function of cyclin-dependent kinase 2 (Cdk2) in neural progenitor cells during postnatal development. Chondroitin sulfate proteoglycan (NG2)-expressing progenitor cells of the subventricular zone (SVZ) show no significant difference in density and proliferation between Cdk2-/- and wild-type mice at perinatal ages and are reduced only in adult Cdk2 -/- mice. Adult Cdk2-/- SVZ cells in culture display decreased self-renewal capacity and enhanced differentiation. Compensatory mechanisms in perinatal Cdk2-/- SVZ cells, which persist until postnatal day 15, involve increased Cdk4 expression that results in retinoblastoma protein inactivation. A subsequent decline in Cdk4 activity to wild-type levels in postnatal day 28 Cdk2-/- cells coincides with lower NG2+ proliferation and self-renewal capacity similar to adult levels. Cdk4 silencing in perinatal Cdk2-/- SVZ cells abolishes Cdk4 up-regulation and reduces cell proliferation and self-renewal to adult levels. Conversely, Cdk4 overexpression in adult SVZ cells restores proliferative capacity to wild-type levels. Thus, although Cdk2 is functionally redundant in perinatal SVZ, it is important for adult progenitor cell proliferation and self-renewal through age-dependent regulation of Cdk4.",
author = "Beata Jablonska and Adan Aguirre and Renaud Vandenbosch and Shibeshih Belachew and Cyril Berthet and Philipp Kaldis and Vittorio Gallo",
year = "2007",
month = dec,
day = "17",
doi = "10.1083/jcb.200702031",
language = "English",
volume = "179",
pages = "1231--1245",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "6",

}