Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

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Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease. / Mattsson, Niklas; Insel, Philip S.; Palmqvist, Sebastian; Portelius, Erik; Zetterberg, Henrik; Weiner, Michael; Blennow, Kaj; Hansson, Oskar.

I: EMBO Molecular Medicine, Vol. 8, Nr. 10, 01.10.2016, s. 1184-1196.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

AU - Mattsson, Niklas

AU - Insel, Philip S.

AU - Palmqvist, Sebastian

AU - Portelius, Erik

AU - Zetterberg, Henrik

AU - Weiner, Michael

AU - Blennow, Kaj

AU - Hansson, Oskar

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) compared to individual biomarkers (T-tau 80.8%; Ng 71.4%; NFL 77.7%). T-tau and Ng were highly correlated (ρ = 0.79, P < 0.001) and strongly associated with β-amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain structure, primarily in people with Aβ pathology. NFL on the other hand was not associated with Aβ pathology and was associated with cognitive decline and brain atrophy independent of Aβ. T-tau, Ng, and NFL provide partly independent information about neuronal injury and may be combined to improve the diagnostic accuracy for AD. T-tau and Ng reflect Aβ-dependent neurodegeneration, while NFL reflects neurodegeneration independently of Aβ pathology.

AB - Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) compared to individual biomarkers (T-tau 80.8%; Ng 71.4%; NFL 77.7%). T-tau and Ng were highly correlated (ρ = 0.79, P < 0.001) and strongly associated with β-amyloid (Aβ) pathology, and with longitudinal deterioration in cognition and brain structure, primarily in people with Aβ pathology. NFL on the other hand was not associated with Aβ pathology and was associated with cognitive decline and brain atrophy independent of Aβ. T-tau, Ng, and NFL provide partly independent information about neuronal injury and may be combined to improve the diagnostic accuracy for AD. T-tau and Ng reflect Aβ-dependent neurodegeneration, while NFL reflects neurodegeneration independently of Aβ pathology.

KW - Alzheimer's

KW - biomarker

KW - CSF

KW - neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=84989947774&partnerID=8YFLogxK

U2 - 10.15252/emmm.201606540

DO - 10.15252/emmm.201606540

M3 - Article

VL - 8

SP - 1184

EP - 1196

JO - EMBO Molecular Medicine

T2 - EMBO Molecular Medicine

JF - EMBO Molecular Medicine

SN - 1757-4684

IS - 10

ER -