Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency

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Abstract

Objectives:

To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.
Material and methods:

Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.
Results:

There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).
Conclusions:

No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

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Nyckelord

Originalspråkengelska
Sidor (från-till)252-257
TidskriftEuropean Journal of Vascular and Endovascular Surgery
Volym14
Utgåva nummer4
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa