Channel current fluctuations conclusively explain neuronal encoding of internal potential into spike trains

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Abstract

Hodgkin and Huxley's seminal neuron model describes the propagation of voltage spikes in axons, but it cannot explain certain full-neuron features crucial for understanding the neural code. We consider channel current fluctuations in a trisection of the Hodgkin-Huxley model, allowing an analytic-mechanistic explanation of these features and yielding consistently excellent matches with in vivo recordings of cerebellar Purkinje neurons, which we use as model systems. This shows that the neuronal encoding is described conclusively by a soft-thresholding function having just three parameters.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Research Institutes of Sweden (RISE)
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biofysik
Originalspråkengelska
Artikelnummer022407
TidskriftPhysical Review E
Volym103
Utgåva nummer2
StatusPublished - 2021
PublikationskategoriForskning
Peer review utfördJa