Characterization of an alternative transcript of the human CREB3L2 gene.

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title = "Characterization of an alternative transcript of the human CREB3L2 gene.",
abstract = "CREB3L2, a member of the CREB3 family of transcription factors, spans >120 kbp and is composed of 12 exons. We characterized a widely expressed transcript of CREB3L2 generated by an intronic polyadenylation site in intron 4 of the gene. It could be translated to a CREB3L2 variant which is localized both in the nucleus and the endoplasmatic reticulum. The protein retains the N-terminal transactivation domain but lacks the DNA-binding domain, the transmembrane domain and the C-terminal part. Experiments using a GAL4 DNA-binding domain fusion model showed that the transcript is a transactivator but it cannot exert its function through the CRE and ATF6 binding sites and has little effect on the GRP78 promoter. Whether this transcript has a cellular function or is targeted for degradation by nonsense-mediated RNA decay system of RNA surveillance is currently unknown.",
author = "Ioannis Panagopoulos and Nastaran Monsef and Anna Collin and Fredrik Mertens",
year = "2010",
doi = "10.3892/or_00000964",
language = "English",
volume = "24",
pages = "1133--1139",
journal = "Oncology Reports",
issn = "1791-2431",
publisher = "D.A. Spandidos",
number = "5",