Characterization of the subventricular zone neurogenic response to rat malignant brain tumors

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The subventricular zone (SVZ) is one of the neurogenic regions of the adult brain. We characterized the neurogenic response of the SVZ to the growth of brain tumors in the rat striatum. Abundant nestin positive cells, most likely representing reactive astrocytes, were found surrounding the tumor. However, we observed no substantial migration of nestin positive cells from the SVZ toward the tumor. Tumor growth resulted in decreased numbers of bromodeoxyuridine positive and Ki-67 positive proliferating cells and a concomitant increase in doublecortin and polysialylated neural cell adhesion molecule immunoreactivity within the SVZ. Neuroblasts were observed in high numbers in the area between the SVZ and the tumor, most likely pointing to the SVZ as the principal source of these cells. Neuroblasts located between the SVZ and the tumor expressed the transcription factor Pbx, a marker for immature striatal neurons. However, no evidence of neuroblast differentiation into fully mature neurons was found. This study thus demonstrates increased neuroblast immunoreactivity within the SVZ ipsilateral to a brain tumor in the striatum. SVZ-derived neuroblasts attracted by the tumor adopt an immature striatal phenotype indicating a region specific reparative mechanism in response to a malignant tumor. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)824-832
TidskriftNeuroscience
Volym147
Utgåva nummer3
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Daniel Bexell, 2008, Avd för Neurokirurgi, Inst för kliniska vetenskaper, Medicinska fakulteten, Lunds Universitet.. 136 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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