Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study

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Characterizing mild cognitive impairment in incident Parkinson disease : the ICICLE-PD study. / Yarnall, Alison J; Breen, David P; Duncan, Gordon W; Khoo, Tien K; Coleman, Shirley Y; Firbank, Michael J; Nombela, Cristina; Winder-Rhodes, Sophie; Evans, Jonathan R; Rowe, James B; Mollenhauer, Brit; Kruse, Niels; Hudson, Gavin; Chinnery, Patrick F; O'Brien, John T; Robbins, Trevor W; Wesnes, Keith; Brooks, David J; Barker, Roger A; Burn, David J; ICICLE-PD Study Group.

I: Neurology, Vol. 82, Nr. 4, 28.01.2014, s. 308-16.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Yarnall, AJ, Breen, DP, Duncan, GW, Khoo, TK, Coleman, SY, Firbank, MJ, Nombela, C, Winder-Rhodes, S, Evans, JR, Rowe, JB, Mollenhauer, B, Kruse, N, Hudson, G, Chinnery, PF, O'Brien, JT, Robbins, TW, Wesnes, K, Brooks, DJ, Barker, RA, Burn, DJ & ICICLE-PD Study Group 2014, 'Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study', Neurology, vol. 82, nr. 4, s. 308-16. https://doi.org/10.1212/WNL.0000000000000066

APA

Yarnall, A. J., Breen, D. P., Duncan, G. W., Khoo, T. K., Coleman, S. Y., Firbank, M. J., ... ICICLE-PD Study Group (2014). Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study. Neurology, 82(4), 308-16. https://doi.org/10.1212/WNL.0000000000000066

CBE

Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ, ICICLE-PD Study Group. 2014. Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study. Neurology. 82(4):308-16. https://doi.org/10.1212/WNL.0000000000000066

MLA

Vancouver

Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ et al. Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study. Neurology. 2014 jan 28;82(4):308-16. https://doi.org/10.1212/WNL.0000000000000066

Author

Yarnall, Alison J ; Breen, David P ; Duncan, Gordon W ; Khoo, Tien K ; Coleman, Shirley Y ; Firbank, Michael J ; Nombela, Cristina ; Winder-Rhodes, Sophie ; Evans, Jonathan R ; Rowe, James B ; Mollenhauer, Brit ; Kruse, Niels ; Hudson, Gavin ; Chinnery, Patrick F ; O'Brien, John T ; Robbins, Trevor W ; Wesnes, Keith ; Brooks, David J ; Barker, Roger A ; Burn, David J ; ICICLE-PD Study Group. / Characterizing mild cognitive impairment in incident Parkinson disease : the ICICLE-PD study. I: Neurology. 2014 ; Vol. 82, Nr. 4. s. 308-16.

RIS

TY - JOUR

T1 - Characterizing mild cognitive impairment in incident Parkinson disease

T2 - the ICICLE-PD study

AU - Yarnall, Alison J

AU - Breen, David P

AU - Duncan, Gordon W

AU - Khoo, Tien K

AU - Coleman, Shirley Y

AU - Firbank, Michael J

AU - Nombela, Cristina

AU - Winder-Rhodes, Sophie

AU - Evans, Jonathan R

AU - Rowe, James B

AU - Mollenhauer, Brit

AU - Kruse, Niels

AU - Hudson, Gavin

AU - Chinnery, Patrick F

AU - O'Brien, John T

AU - Robbins, Trevor W

AU - Wesnes, Keith

AU - Brooks, David J

AU - Barker, Roger A

AU - Burn, David J

AU - ICICLE-PD Study Group

PY - 2014/1/28

Y1 - 2014/1/28

N2 - OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.

AB - OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.

KW - Aged

KW - Aged, 80 and over

KW - Amyloid beta-Peptides

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Intermediate Filament Proteins

KW - Male

KW - Middle Aged

KW - Mild Cognitive Impairment

KW - Neuropsychological Tests

KW - Parkinson Disease

KW - Peptide Fragments

KW - Retrospective Studies

KW - Severity of Illness Index

KW - tau Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1212/WNL.0000000000000066

DO - 10.1212/WNL.0000000000000066

M3 - Article

VL - 82

SP - 308

EP - 316

JO - Neurology

JF - Neurology

SN - 1526-632X

IS - 4

ER -