Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.

Detaljer

Författare
  • Russell A Hermansen
  • Brian K Mannakee
  • Wolfgang Knecht
  • David A Liberles
  • Ryan N Gutenkunst
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cellbiologi
Originalspråkengelska
Artikelnummer232
TidskriftBMC Evolutionary Biology
Volym15
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa