Chemokine receptor expression defines heterogeneity in the earliest thymic migrants

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.

Detaljer

Författare
  • William E. Jenkinson
  • Simona W. Rossi
  • Sonia Parnell
  • William Agace
  • Yousuke Takahama
  • Eric J. Jenkinson
  • Graham Anderson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)2090-2096
TidskriftEuropean Journal of Immunology
Volym37
Utgivningsnummer8
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa