Chemokine receptor expression defines heterogeneity in the earliest thymic migrants

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Chemokine receptor expression defines heterogeneity in the earliest thymic migrants. / Jenkinson, William E.; Rossi, Simona W.; Parnell, Sonia; Agace, William; Takahama, Yousuke; Jenkinson, Eric J.; Anderson, Graham.

I: European Journal of Immunology, Vol. 37, Nr. 8, 2007, s. 2090-2096.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Jenkinson, WE, Rossi, SW, Parnell, S, Agace, W, Takahama, Y, Jenkinson, EJ & Anderson, G 2007, 'Chemokine receptor expression defines heterogeneity in the earliest thymic migrants', European Journal of Immunology, vol. 37, nr. 8, s. 2090-2096. https://doi.org/10.1002/eji.200737212

APA

Jenkinson, W. E., Rossi, S. W., Parnell, S., Agace, W., Takahama, Y., Jenkinson, E. J., & Anderson, G. (2007). Chemokine receptor expression defines heterogeneity in the earliest thymic migrants. European Journal of Immunology, 37(8), 2090-2096. https://doi.org/10.1002/eji.200737212

CBE

MLA

Vancouver

Author

Jenkinson, William E. ; Rossi, Simona W. ; Parnell, Sonia ; Agace, William ; Takahama, Yousuke ; Jenkinson, Eric J. ; Anderson, Graham. / Chemokine receptor expression defines heterogeneity in the earliest thymic migrants. I: European Journal of Immunology. 2007 ; Vol. 37, Nr. 8. s. 2090-2096.

RIS

TY - JOUR

T1 - Chemokine receptor expression defines heterogeneity in the earliest thymic migrants

AU - Jenkinson, William E.

AU - Rossi, Simona W.

AU - Parnell, Sonia

AU - Agace, William

AU - Takahama, Yousuke

AU - Jenkinson, Eric J.

AU - Anderson, Graham

PY - 2007

Y1 - 2007

N2 - Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.

AB - Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.

KW - chemokine receptor

KW - colonization

KW - T cell

KW - thymus

U2 - 10.1002/eji.200737212

DO - 10.1002/eji.200737212

M3 - Article

VL - 37

SP - 2090

EP - 2096

JO - European Journal of Immunology

T2 - European Journal of Immunology

JF - European Journal of Immunology

SN - 1521-4141

IS - 8

ER -