Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18±4.7 U/mg protein) compared to the control rats (100±22 U/mg protein; p

Detaljer

Författare
  • N. Clyne
  • C. Hofman-Bang
  • Y. Haga
  • N. Hatori
  • S. L. Marklund
  • S. K. Pehrsson
  • R. Wibom
Externa organisationer
  • Karolinska University Hospital
  • Norrland University Hospital
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)609-614
Antal sidor6
TidskriftScandinavian Journal of Clinical & Laboratory Investigation
Volym61
Utgivningsnummer8
StatusPublished - 2001
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa