Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

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title = "Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition",
abstract = "Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95{\%} confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.",
keywords = "biomarker, EPIC, height, insulin-like growth factor I, melanoma, prospective studies",
author = "Bradbury, {Kathryn E.} and Appleby, {Paul N.} and Tipper, {Sarah J.} and Travis, {Ruth C.} and Allen, {Naomi E.} and Marina Kvaskoff and Kim Overvad and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Iris Cervenka and Yahya Mahamat-Saleh and Fabrice Bonnet and Rudolf Kaaks and Fortner, {Ren{\'e}e T.} and Heiner Boeing and Antonia Trichopoulou and {La Vecchia}, Carlo and Stratigos, {Alexander J.} and Domenico Palli and Sara Grioni and Giuseppe Matullo and Salvatore Panico and Rosario Tumino and Peeters, {Petra H.} and Bueno-de-Mesquita, {H. Bas} and Reza Ghiasvand and Veier{\o}d, {Marit B.} and Elisabete Weiderpass and Catalina Bonet and Elena Molina and Huerta, {Jos{\'e} M.} and Nerea Larra{\~n}aga and Aurelio Barricarte and Susana Merino and Karolin Isaksson and Tanja Stocks and Ingrid Ljuslinder and Oskar Hemmingsson and Nick Wareham and Khaw, {Kay Tee} and Gunter, {Marc J.} and Sabina Rinaldi and Tsilidis, {Konstantinos K.} and Dagfinn Aune and Elio Riboli and Key, {Timothy J.}",
year = "2019",
doi = "10.1002/ijc.31854",
language = "English",
volume = "144",
pages = "957--966",
journal = "Acta - Unio Internationalis Contra Cancrum",
issn = "0020-7136",
publisher = "John Wiley & Sons",
number = "5",