Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

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Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition. / Bradbury, Kathryn E.; Appleby, Paul N.; Tipper, Sarah J.; Travis, Ruth C.; Allen, Naomi E.; Kvaskoff, Marina; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Cervenka, Iris; Mahamat-Saleh, Yahya; Bonnet, Fabrice; Kaaks, Rudolf; Fortner, Renée T.; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Stratigos, Alexander J.; Palli, Domenico; Grioni, Sara; Matullo, Giuseppe; Panico, Salvatore; Tumino, Rosario; Peeters, Petra H.; Bueno-de-Mesquita, H. Bas; Ghiasvand, Reza; Veierød, Marit B.; Weiderpass, Elisabete; Bonet, Catalina; Molina, Elena; Huerta, José M.; Larrañaga, Nerea; Barricarte, Aurelio; Merino, Susana; Isaksson, Karolin; Stocks, Tanja; Ljuslinder, Ingrid; Hemmingsson, Oskar; Wareham, Nick; Khaw, Kay Tee; Gunter, Marc J.; Rinaldi, Sabina; Tsilidis, Konstantinos K.; Aune, Dagfinn; Riboli, Elio; Key, Timothy J.

I: International Journal of Cancer, Vol. 144, Nr. 5, 2019, s. 957-966.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Bradbury, KE, Appleby, PN, Tipper, SJ, Travis, RC, Allen, NE, Kvaskoff, M, Overvad, K, Tjønneland, A, Halkjær, J, Cervenka, I, Mahamat-Saleh, Y, Bonnet, F, Kaaks, R, Fortner, RT, Boeing, H, Trichopoulou, A, La Vecchia, C, Stratigos, AJ, Palli, D, Grioni, S, Matullo, G, Panico, S, Tumino, R, Peeters, PH, Bueno-de-Mesquita, HB, Ghiasvand, R, Veierød, MB, Weiderpass, E, Bonet, C, Molina, E, Huerta, JM, Larrañaga, N, Barricarte, A, Merino, S, Isaksson, K, Stocks, T, Ljuslinder, I, Hemmingsson, O, Wareham, N, Khaw, KT, Gunter, MJ, Rinaldi, S, Tsilidis, KK, Aune, D, Riboli, E & Key, TJ 2019, 'Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition', International Journal of Cancer, vol. 144, nr. 5, s. 957-966. https://doi.org/10.1002/ijc.31854

APA

Bradbury, K. E., Appleby, P. N., Tipper, S. J., Travis, R. C., Allen, N. E., Kvaskoff, M., ... Key, T. J. (2019). Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition. International Journal of Cancer, 144(5), 957-966. https://doi.org/10.1002/ijc.31854

CBE

Bradbury KE, Appleby PN, Tipper SJ, Travis RC, Allen NE, Kvaskoff M, Overvad K, Tjønneland A, Halkjær J, Cervenka I, Mahamat-Saleh Y, Bonnet F, Kaaks R, Fortner RT, Boeing H, Trichopoulou A, La Vecchia C, Stratigos AJ, Palli D, Grioni S, Matullo G, Panico S, Tumino R, Peeters PH, Bueno-de-Mesquita HB, Ghiasvand R, Veierød MB, Weiderpass E, Bonet C, Molina E, Huerta JM, Larrañaga N, Barricarte A, Merino S, Isaksson K, Stocks T, Ljuslinder I, Hemmingsson O, Wareham N, Khaw KT, Gunter MJ, Rinaldi S, Tsilidis KK, Aune D, Riboli E, Key TJ. 2019. Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition. International Journal of Cancer. 144(5):957-966. https://doi.org/10.1002/ijc.31854

MLA

Vancouver

Author

Bradbury, Kathryn E. ; Appleby, Paul N. ; Tipper, Sarah J. ; Travis, Ruth C. ; Allen, Naomi E. ; Kvaskoff, Marina ; Overvad, Kim ; Tjønneland, Anne ; Halkjær, Jytte ; Cervenka, Iris ; Mahamat-Saleh, Yahya ; Bonnet, Fabrice ; Kaaks, Rudolf ; Fortner, Renée T. ; Boeing, Heiner ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Stratigos, Alexander J. ; Palli, Domenico ; Grioni, Sara ; Matullo, Giuseppe ; Panico, Salvatore ; Tumino, Rosario ; Peeters, Petra H. ; Bueno-de-Mesquita, H. Bas ; Ghiasvand, Reza ; Veierød, Marit B. ; Weiderpass, Elisabete ; Bonet, Catalina ; Molina, Elena ; Huerta, José M. ; Larrañaga, Nerea ; Barricarte, Aurelio ; Merino, Susana ; Isaksson, Karolin ; Stocks, Tanja ; Ljuslinder, Ingrid ; Hemmingsson, Oskar ; Wareham, Nick ; Khaw, Kay Tee ; Gunter, Marc J. ; Rinaldi, Sabina ; Tsilidis, Konstantinos K. ; Aune, Dagfinn ; Riboli, Elio ; Key, Timothy J. / Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition. I: International Journal of Cancer. 2019 ; Vol. 144, Nr. 5. s. 957-966.

RIS

TY - JOUR

T1 - Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

AU - Bradbury, Kathryn E.

AU - Appleby, Paul N.

AU - Tipper, Sarah J.

AU - Travis, Ruth C.

AU - Allen, Naomi E.

AU - Kvaskoff, Marina

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Cervenka, Iris

AU - Mahamat-Saleh, Yahya

AU - Bonnet, Fabrice

AU - Kaaks, Rudolf

AU - Fortner, Renée T.

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - La Vecchia, Carlo

AU - Stratigos, Alexander J.

AU - Palli, Domenico

AU - Grioni, Sara

AU - Matullo, Giuseppe

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Peeters, Petra H.

AU - Bueno-de-Mesquita, H. Bas

AU - Ghiasvand, Reza

AU - Veierød, Marit B.

AU - Weiderpass, Elisabete

AU - Bonet, Catalina

AU - Molina, Elena

AU - Huerta, José M.

AU - Larrañaga, Nerea

AU - Barricarte, Aurelio

AU - Merino, Susana

AU - Isaksson, Karolin

AU - Stocks, Tanja

AU - Ljuslinder, Ingrid

AU - Hemmingsson, Oskar

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Gunter, Marc J.

AU - Rinaldi, Sabina

AU - Tsilidis, Konstantinos K.

AU - Aune, Dagfinn

AU - Riboli, Elio

AU - Key, Timothy J.

PY - 2019

Y1 - 2019

N2 - Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

AB - Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

KW - biomarker

KW - EPIC

KW - height

KW - insulin-like growth factor I

KW - melanoma

KW - prospective studies

U2 - 10.1002/ijc.31854

DO - 10.1002/ijc.31854

M3 - Article

VL - 144

SP - 957

EP - 966

JO - Acta - Unio Internationalis Contra Cancrum

T2 - Acta - Unio Internationalis Contra Cancrum

JF - Acta - Unio Internationalis Contra Cancrum

SN - 0020-7136

IS - 5

ER -