Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Phytoestrogens may influence prostate cancer development. This study aimed to examine the association between prediagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and the risk of prostate cancer. Individual participant data were available from seven prospective studies (two studies from Japan with 241 cases and 503 controls and five studies from Europe with 2,828 cases and 5,593 controls). Because of the large difference in circulating isoflavone concentrations between Japan and Europe, analyses of the associations of isoflavone concentrations and prostate cancer risk were evaluated separately. Prostate cancer risk by study-specific fourths of circulating concentrations of each phytoestrogen was estimated using multivariable-adjusted conditional logistic regression. In men from Japan, those with high compared to low circulating equol concentrations had a lower risk of prostate cancer (multivariable-adjusted OR for upper quartile [Q4] vs. Q1 = 0.61, 95% confidence interval [CI] = 0.39–0.97), although there was no significant trend (OR per 75 percentile increase = 0.69, 95 CI = 0.46–1.05, ptrend = 0.085); Genistein and daidzein concentrations were not significantly associated with risk (ORs for Q4 vs. Q1 = 0.70, 0.45–1.10 and 0.71, 0.45–1.12, respectively). In men from Europe, circulating concentrations of genistein, daidzein and equol were not associated with risk. Circulating lignan concentrations were not associated with the risk of prostate cancer, overall or by disease aggressiveness or time to diagnosis. There was no strong evidence that prediagnostic circulating concentrations of isoflavones or lignans are associated with prostate cancer risk, although further research is warranted in populations where isoflavone intakes are high.


  • Aurora Perez-Cornago
  • Paul N. Appleby
  • Heiner Boeing
  • Leire Gil
  • Cecilie Kyrø
  • Fulvio Ricceri
  • Neil Murphy
  • Antonia Trichopoulou
  • Konstantinos K. Tsilidis
  • Kay Tee Khaw
  • Robert N. Luben
  • Randi E. Gislefoss
  • Hilde Langseth
  • Pär Stattin
  • Anders Johansson
  • Rikard Landberg
  • Lena Maria Nilsson
  • Kotaro Ozasa
  • Akiko Tamakoshi
  • Kazuya Mikami
  • Tatsuhiko Kubo
  • Norie Sawada
  • Shoichiro Tsugane
  • Timothy J. Key
  • Naomi E. Allen
  • Ruth C. Travis
Enheter & grupper
Externa organisationer
  • University of Oxford
  • German Institute of Human Nutrition
  • Danish Cancer Society Research Center
  • University of Turin
  • International Agency for Research on Cancer, World Health Organization
  • Hellenic Health Foundation, Athens
  • Imperial College London
  • University of Ioannina
  • University of Cambridge
  • Cancer Registry of Norway Institute of Population-Based Cancer Research
  • Skåne University Hospital
  • Uppsala universitet, Historiska institutionen
  • Umeå University
  • Chalmers University of Technology
  • Radiation Effects Research Foundation Hiroshima
  • University of Occupational and Environmental Health, Japan
  • National Cancer Center Tokyo
  • CIBER Epidemiology and Public Health (CIBERESP)

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi


Sidor (från-till)2677-2686
TidskriftInternational Journal of Cancer
Tidigt onlinedatum2018 jan 1
StatusPublished - 2018
Peer review utfördJa