Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray"

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Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray". / Brans, B.; Bodei, L.; Giammarile, F.; Lindén, Ola; Luster, M.; Oyen, W. J. G.; Tennvall, Jan.

I: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 34, Nr. 5, 2007, s. 772-786.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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Brans, B. ; Bodei, L. ; Giammarile, F. ; Lindén, Ola ; Luster, M. ; Oyen, W. J. G. ; Tennvall, Jan. / Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray". I: European Journal of Nuclear Medicine and Molecular Imaging. 2007 ; Vol. 34, Nr. 5. s. 772-786.

RIS

TY - JOUR

T1 - Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray"

AU - Brans, B.

AU - Bodei, L.

AU - Giammarile, F.

AU - Lindén, Ola

AU - Luster, M.

AU - Oyen, W. J. G.

AU - Tennvall, Jan

PY - 2007

Y1 - 2007

N2 - Introduction Radionuclide therapy has distinct similarities to, but also profound differences from external radiotherapy. Review This review discusses techniques and results of previously developed dosimetry methods in thyroid carcinoma, neuro-endocrine tumours, solid tumours and lymphoma. In each case, emphasis is placed on the level of evidence and practical applicability. Although dosimetry has been of enormous value in the preclinical phase of radiopharmaceutical development, its clinical use to optimise administered activity on an individual patient basis has been less evident. In phase I and II trials, dosimetry may be considered an inherent part of therapy to establish the maximum tolerated dose and dose-response relationship. To prove that dosimetry-based radionuclide therapy is of additional benefit over fixed dosing or dosing per kilogram body weight, prospective randomised phase III trials with appropriate end points have to be undertaken. Data in the literature which underscore the potential of dosimetry to avoid under- and overdosing and to standardise radionuclide therapy methods internationally are very scarce. Developments In each section, particular developments and insights into these therapies are related to opportunities for dosimetry. The recent developments in PET and PET/CT imaging, including micro-devices for animal research, and molecular medicine provide major challenges for innovative therapy and dosimetry techniques. Furthermore, the increasing scientific interest in the radiobiological features specific to radionuclide therapy will advance our ability to administer this treatment modality optimally.

AB - Introduction Radionuclide therapy has distinct similarities to, but also profound differences from external radiotherapy. Review This review discusses techniques and results of previously developed dosimetry methods in thyroid carcinoma, neuro-endocrine tumours, solid tumours and lymphoma. In each case, emphasis is placed on the level of evidence and practical applicability. Although dosimetry has been of enormous value in the preclinical phase of radiopharmaceutical development, its clinical use to optimise administered activity on an individual patient basis has been less evident. In phase I and II trials, dosimetry may be considered an inherent part of therapy to establish the maximum tolerated dose and dose-response relationship. To prove that dosimetry-based radionuclide therapy is of additional benefit over fixed dosing or dosing per kilogram body weight, prospective randomised phase III trials with appropriate end points have to be undertaken. Data in the literature which underscore the potential of dosimetry to avoid under- and overdosing and to standardise radionuclide therapy methods internationally are very scarce. Developments In each section, particular developments and insights into these therapies are related to opportunities for dosimetry. The recent developments in PET and PET/CT imaging, including micro-devices for animal research, and molecular medicine provide major challenges for innovative therapy and dosimetry techniques. Furthermore, the increasing scientific interest in the radiobiological features specific to radionuclide therapy will advance our ability to administer this treatment modality optimally.

KW - radio-immunotherapy

KW - neuro-endocrine tumours

KW - carcinoma

KW - thyroid

KW - radiotherapy

KW - radionuclide therapy

KW - radiation dosimetry

KW - solid tumours

KW - lymphoma

U2 - 10.1007/s00259-006-0338-5

DO - 10.1007/s00259-006-0338-5

M3 - Review article

VL - 34

SP - 772

EP - 786

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 5

ER -